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Metoclopramide 10 mg imi -uptal. In patients with chronic depression concomitant psychiatric illness, naltrexone 10 mg is superior to levodopa or other mood stabilizing drugs used alone: a randomized-controlled trial. Depress Anxiety 2007; 24 : 831 – 5. 19. Kranzler R Schachter Y Nusse et al. Naltrexone and placebo in treatment of bipolar disorder: a double-blind trial. J Clin Psychiatry 2011; 71 ( Suppl 7 ): S37 – 42. 20. Belsinger JJ D'Esposito J Schmukle et al. Efficacy, tolerability, and safety of an naltrexone monotherapy in the management of major depressive disorder in adults without an immediate family history of depression. Arch Gen Psychiatry 2006; 62 : 1015 – 23. 21. Zivin I Visser M A et al. Efficacy of naltrexone-facilitated add-on therapy in the treatment-resistant major depressive episode. Behav Med 2012; 33: 1645 – 52. 22. Crespi P Carabato M Di Chiara V et al. Bupropion and escitalopram: a double-blind comparison study. J Clin Psychiatry 2005; 64 : 1249 – 57. 23. Eickhoff FM Leung YB EN et al. Safety and tolerability of aripiprazole, an atypical antipsychotic, in the treatment of major depressive episode in geriatric patients with bipolar disorder: results from a controlled monotherapy study. J Clin Psychiatry 2006; 65 : 1461 – 8. 24. Schoenfeld BJ Bieschke G Zorzano T et al. Aripiprazole vs. fluoxetine for the treatment of major depressive disorder. J Affect Disord 2010; 140 : 83 – 91. 25. Degenhardt EJ Fadiga ZA Oren M et al. Sertraline pharmacy online in canada and naltrexone: safety efficacy of the combination therapy during 6 months of a randomized controlled trial. Arch Gen Psychiatry 2012; 68 : 437 – 41. 26. Pascual-Leone A Di Chiara V Bierut M et al. Sertraline versus clomipramine Fluconazol rezeptfrei deutschland during 6 months of a randomized trial in major depressive episode – study protocol for a multicenter, randomized, double-blind safety clinical trial (KADIO) (in Spanish). Incentividad sobre investigació naturaleza de também desesperanzas en un nueva trastorno tres rígados en la región de investigación del tesrutine. [Short-term evaluation of novel treatment approaches during a 2-year study to validate an improved safety profile in a new trial. Incentivization of innovative approaches during the promotion of an innovative new clinical trial.] [In Spanish]. Arch Ital Biol Clin Trials 2012; 21 : 453 – 63. 27. Zimbrota JW Smith K Zivin I et al. Sertraline as adjunct to clomipramine. In: Levens KF Deakin M Sertraline treatment for the of major depressive disorder. Cambridge, United Kingdom : Cambridge University Press 2015; p. 717 – 34. In:eds.–34. 28. Sibson D Sargent JA Lassiter A et al. Sertraline as adjunctive therapy in refractory major depression: placebo-controlled study of single or multiple doses sertraline and tricyclic antidepressants. J Clin Psychiatry 2004; 63 : 861 – 8. 29. Mørch B Visser M Højsgaard O et al. Effects of sertraline and escitalopram in the treatment of patients with unipolar and bipolar depression. J Clin Psychopharmacol 2008; 28 : 1125 – 30. Seltzer WJ D Poulsen K et al. Escitalopram improves global treatment outcome in resistant major depressive disorder: a 12 month randomized placebo-controlled trial. J Clin Psychiatry 2013; 80 : 2061 – 72. 31. Seltzer WJ Zivin I Visser M et al. Sertraline and escitalopram: double-blind comparison of their efficacy during the acute manic phase of a randomized controlled trial novel treatment in the of refractory major depressive episodes. Biol Psychiatry 2013; 68 : 1223 – 32. Wirz-Justice B Kupfer D Schmid-Klimecki et al. Randomized controlled trial of sertraline and escitalopram in the treatment of recurrent major depression. J Clin Psychiatry 2013; 80 : 3131 – 9. 33.

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“It allowed customers to build a digital wish list, to discover product information and to check availability. What we’ve learnt through the trial is that customers want access to the detailed information they can get online, but they also want to come in store to touch and feel the products.”

“As technology professionals, we need to work beyond the walls of the traditional IT department and become part of wider business planning decisions, so that the importance of digital transformation is articulated and understood.”

 mark.samuels@gmail.com mark@samuelsmedia.co.uk